Medicine Pansystolic murmur at apex with soft first heart sound is the key sign of which one of the following ? A Aortic regurgitation B Mitral regurgitation C Ventricular septal defect D Atrial septal defect 💡 Explanation Pansystolic murmur at apex with soft first heart sound is the key sign of which one of the following ? ✓ Correct Answer: B. Mitral regurgitation