Non Palpable purpura is seen in A/E
**Core Concept**
Non-palpable purpura is a type of skin manifestation characterized by pinpoint, small, and flat hemorrhages, typically seen in conditions affecting blood vessel integrity, coagulation, or vascular permeability. These lesions are usually not raised above the skin surface and may not be palpable.
**Why the Correct Answer is Right**
Non-palpable purpura is a hallmark of Henoch-Schönlein purpura (HSP), a form of vasculitis that affects small vessels and is associated with IgA deposition. In HSP, the purpura typically appears as a result of immune complex deposition and complement activation, leading to inflammation and damage to the blood vessel walls. This results in leakage of red blood cells into the skin, producing the characteristic non-palpable purpura.
**Why Each Wrong Option is Incorrect**
**Option A:** Although thrombocytopenia can cause purpura, it typically results in larger, more raised lesions due to platelet deficiency.
**Option B:** Diabetes mellus does not directly cause non-palpable purpura, but can lead to vascular complications such as microangiopathy, which may cause purpura.
**Option C:** In contrast to HSP, systemic lupus erythematosus (SLE) often presents with palpable purpura, particularly in the context of vasculitis.
**Clinical Pearl / High-Yield Fact**
Remember that HSP typically affects children and young adults, and is characterized by a classic tetrad of symptoms: non-palpable purpura, arthralgias, gastrointestinal symptoms, and renal involvement.
**Correct Answer:** B. Diabetes mellus