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59761 Medicine

A 34-year-old man presents to the emergency department with symptoms of fatigue, weakness, nose bleeds, and palpitations with exertion. The symptoms started 1 week ago and are getting worse every day. He has no prior health issues and is not taking any medications. On examination, he is pale, blood pressure 110/70 mm Hg, pulse 100/min, heart sounds are normal, lungs are clear, and he has multiple petechiae and bruises on his legs.His blood count is abnormal; hemoglobin 8.5 g/dL, white blood cells (WBCs) 4000/mL, platelets 50,000/mL, and there are blast cells in the peripheral blood. He is diagnosed with acute promyelocytic leukemia (AML-M3). (See Figure below) Which of the following is a characteristic of this acute myelogenous leukemia?

Apeak incidence in childhood
Bhigh leukocyte alkaline phosphatase
CPhiladelphia chromosome
DAuer bodies in blast cells
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