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57479 Surgery

In an evaluation of an 8-year-old boy who has had recurrent infections since the first year of life, findings include enlargement of the liver and spleen, lymph node inflammation, and a superficial dermatitis resembling eczema. Microscopic examination of a series of peripheral blood smears taken during the course of a staphylococcal infection indicates that the bactericidal capacity of the boy’s neutrophils is impaired or absent. What is the most likely cause of this child’s illness?

ADefect in the enzyme NADPH oxidase
BDefect in the enzyme adenosine deaminase (ADA)
CDefect in the IL-2 receptor
DDevelopmental defect at the pre-B stage
Surgery
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