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43725 Physiology

A woman who is heterozygous for glucose-6-phosphate dehydrogenase (G6PD), a polymorphic enzyme transcribed from the X chromosome, develops chronic myeloid leukemia. Restriction fragment length polymorphism (RFLP) studies on the tumor cells for G6PD reveal that only a single form of the enzyme is transcribed. This finding suppos which of the following features of neoplasia?

AGenetic mutation
BMonoclonality
CMosaicism
DOncogene activation
Physiology
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43730 Surgery

A 26 year old engineering student presented to the emergency with pain in the wrist after a fall on an outstretched hand from the motorcycle travelling at a very high speed. Examination shows swelling, diffuse tenderness, deformity, and limited wrist movement. ‘Spilled teacup’ sign is seen on a PA view X-ray wrist. What is the likely diagnosis?

AScaphoid fractures
BPerilunate dislocation
CPost-traumatic ahritis
DFracture of radial styloid
Surgery
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