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33229 Anaesthesia

A 55-year-old woman was admitted to the intensive care unit with severe lobar pneumonia and septic shock. She remained hypoxemic despite intubation, a high fraction of inspired oxygen, and positive end-expiratory pressure (PEEP). When PEEP was increased further, she paradoxically became more hypoxemic and her blood pressure and central venous hemoglobin saturation fell. What would be your approach

AKeep PEEP at the highest and give adrenaline
BInitiate dobutamine and reduce PEEP to 5cm H2O
CIncrease PEEP further
DIncrease FiO2
Anaesthesia
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33231 Unknown

A 30-year-old male presented to the OPD with complaints of dark-coloured urine for 1 week. The episodes usually occur in the night. No splenomegaly was observed on examination. Lab findings revealed, Increased indirect bilirubin Hemoglobinemia and hemoglobinuria Absent haptoglobin Raised LDH Hemosiderinuria Reticulocytosis Flow cytometry studies were done The drug which has been approved for the above condition works by blocking which component of the complement system: –

AC3a
BC5
CMAC complex
DC1q
Unknown
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