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21044 Surgery

As compared with the early immunosuppressive drugs (azathioprine, steroids, anti-lymphocyte serum) some newer agents have the following specific advantages:

ACyclosporine, which interferes with lymphokine production, exhibits neither bone marrow nor renal toxicity
BMonoclonal antibody (OKT3) is more available and has greater specificity and fewer side effects than anti-lymphocyte serum
CTacrolimus (FK506) has propeies similar to those of cyclosporine but is especially valuable for rescue of grafts that are failing on cyclosporine therapy
DNone of the above
Surgery
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21048 Biochemistry

A newborn infant refuses breast milk since the 2nd day of bih, vomits on force-feeding but accepts glucose-water, develops diarrhea on the third day, by 5th day she is jaundiced with liver enlargement and eyes show signs of cataract. Urinary reducing sugar was positive but blood glucose estimated by glucose oxidation method was found low. The most likely cause is deficiency of :

AGalactose-1-phosphate uridyl transferase.
BBeta galactosidase
CGlucose-6-phosphatase
DGalactokinase
Biochemistry
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