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185502 Pathology

An 80-year-old woman presents with a 4-hour history of fever, shaking chills, and disorientation. Her blood pressure is 80/40 mm Hg. Physical examination shows diffuse purpura on her upper arms and chest. Blood cultures are positive for Gram-negative organism. Which of the following cytokines is primarily involved in the pathogenesis of direct vascular injury in this patient with septic shock?

AInterferon-g
BTransforming Growth Factor-b (TGFb)
CPlatelet-derived growth factor
DTumor necrosis factor-a
Pathology
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