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181551 Medicine

A 20-year-old woman complains of weakness that is worse in the afternoon, worse during prolonged activity, and improved by rest. When fatigued, the patient is unable to hold her head up or chew her food. She often notes diplopia when driving home from work. On physical examination, she has no loss of reflexes, sensation, or coordination. Which of the following is the likely pathogenesis of this disease?

AAutoantibodies directed against the postsynaptic acetylcholine receptor causing neuromuscular transmission failure
BDestruction of anterior horn cells by virus
CProgressive muscular atrophy caused by spinal degeneration
DDemyelinating disease
Medicine
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