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174105 Pathology

A perimenopausal woman presents with increasing swallowing difficulty and fatigue. Physical examination reveals that her thyroid is enlarged (palpable goiter). Laboratory examination of her serum reveals T4 of 4.9 mg/dL, free T4 of 2.5 ng/dL, and TSH of 5.5 mIU/mL. No thyroidstimulating immunoglobulins are identified in the serum, but antimicrosomal antibodies are present. Which one of the listed histologic findings, if present in a thyroid biopsy from this individual, would be most consistent with a diagnosis of Hashimoto’s thyroiditis?

ALymphocytic infiltrate without follicle formation
BIntense lymphoplasmacytic infiltrate with lymphoid follicles and scattered oxyphilic cells
CHyperplasia of follicular cells with scalloping of colloid at the margin of follicles
DGranulomatous inflammation with multinucleated giant cells surrounding fragments of colloid
Pathology
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