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171259 Medicine

A 62-year-old man reports early satiety, fatigue, and generally feeling unwell. On examination he has a large spleen, appears pale, and the rest of the examination is normal. His blood count is abnormal; the WBC is 50,000/mL with increased mature granulocytes, hemoglobin 9.5 g/dL, and platelets 450,000/mL. Which of the following cytogenetic changes is most characteristic of his condition?

Adeletion of chromosome 14
Breciprocal translocation of 9 and 22 (Philadelphia chromosome)
Ctranslocation of the renal artery stenosis (RAS) oncogene
Dtrisomy 21
Medicine
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