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147619 Medicine

A 70 year old male patient dies with severe dementia. Autopsy demonstrates marked atrophy of the frontal and temporal lobes, with relative sparing of the rest of the brain. Which of the following microscopic features would be most useful in establishing the diagnosis?

AEnlarged presynaptic axon terminals surrounding a central core of extracellular amyloid-like substance
BIntracytoplasmic spherules composed of paired helical filaments
CIntracytoplasmic spherules that stain brightly eosinophilic
DIntranuclear and intracytoplasmic inclusion bodies in enlarged cells
Medicine
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