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134971 Pathology

A 60-year-old man is referred for evaluation of marked erythrocytosis and splenomegaly. Laboratory studies confirm an elevated red blood cell count and additionally demonstrate a moderate increase in circulating granulocytes and platelets. Oxygen saturation studies are normal, and isotopic studies reveal an increase in total red cell mass. Which of the following is characteristic of this disorder?

AFrequent association with thrombosis or hemorrhagic phenomena
BIncreased erythropoietin concentration
CManifestation of Cushing syndrome
DMost often secondary to hypoxia
Pathology
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