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10108 Medicine

A 60 year old male was diagnosed with end stage kidney disease 5 years ago & has been managed with hemodialysis since then. He is also hypeensive & diabetic. He is not compliant with his medications & hemodialysis schedule & now presented with bone pain & dyspnea. CXR shows hazy bilateral infiltrates. Chest CT shows ground-glass infiltrates bilaterally. Lab studies show elevated levels of calcium & phosphate, PTH levels of 130 pg/ml. What would be the best management for this patient?

ACalcitriol 0.5 mg IV with hemodialysis with sevelamer three times daily
BCalcitriol 0.5 mg orally daily with sevelamer 1600 mg three times daily
CMore aggressive hemodialysis to achieve optimal fluid and electrolyte balance
DParathyroidectomy
Medicine
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10110 Anatomy

A 50-year-old pulmonologist is diagnosed with pulmonary tuberculosis and staed on standard drug therapy. After 1.5 months, the patient has developed fatigue, low grade fever, muscle aches, bone pains and body aches. The patient also complains of pleuritic chest pain. His sputum tests negative for acid fast bacilli. On fuher investigations, the patient tests positive for anti-histone antibodies. Abnormality in which of the following metabolic processes is responsible for patient’s current condition?

ASulfation
BGlucuronide conjugation
CAcetylation
DHydroxylation
Anatomy
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