## **Core Concept**
The question assesses the ability to diagnose a condition characterized by recurrent infections and gastrointestinal symptoms. The key features here are recurrent chest infections, fever, and foul-smelling stools, which point towards an underlying condition affecting both the respiratory and gastrointestinal systems.
## **Why the Correct Answer is Right**
The correct answer, **Cystic Fibrosis (CF)**, is a genetic disorder that affects the lungs, pancreas, and other organs. It is caused by mutations in the **CFTR (cystic fibrosis transmembrane conductance regulator) gene**, leading to the production of thick and sticky mucus. This mucus clogs the airways and traps bacteria, resulting in recurrent **chest infections**. Additionally, it blocks the release of digestive enzymes from the pancreas, leading to **malabsorption and foul-smelling stools (steatorrhea)**. The combination of respiratory and gastrointestinal symptoms makes CF a likely diagnosis.
## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because, without specifying the condition, it's impossible to assess its relevance. However, given the symptoms, it's clear that a condition affecting both respiratory and gastrointestinal systems is needed.
- **Option B:** Similarly, this option lacks specificity. If it doesn't directly relate to a condition causing both recurrent chest infections and gastrointestinal symptoms like foul-smelling stools, it's incorrect.
- **Option D:** This option is incorrect if it doesn't align with the symptomatology provided. Conditions that only affect either the respiratory or gastrointestinal system without the specific combination of symptoms described would not be correct.
## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that **Cystic Fibrosis** is often diagnosed in childhood and is characterized by the triad of **respiratory symptoms (like recurrent bronchopulmonary infections), gastrointestinal symptoms (such as malabsorption and steatorrhea), and salty sweat**. A diagnostic test for CF is the **sweat chloride test**, which measures the amount of chloride in sweat.
## **Correct Answer:** C. Cystic Fibrosis.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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