**Core Concept**
The oxygen dissociation curve is a graphical representation of the relationship between the partial pressure of oxygen and the saturation of hemoglobin with oxygen. A shift to the right indicates that hemoglobin releases oxygen more easily, while a shift to the left indicates that hemoglobin holds onto oxygen more tightly.
**Why the Correct Answer is Right**
A right shift of the oxygen dissociation curve is caused by an increase in the concentration of 2,3-bisphosphoglycerate (2,3-BPG) in red blood cells. 2,3-BPG binds to hemoglobin, reducing its affinity for oxygen and facilitating the release of oxygen to tissues. This is particularly important in conditions of high metabolic demand, such as exercise or fever, when tissues require more oxygen.
**Why Each Wrong Option is Incorrect**
**Option A:** This is a distractor, as there is no clear mechanism by which acidosis would cause a right shift of the oxygen dissociation curve.
**Option B:** While carbon dioxide does affect the oxygen dissociation curve, its primary effect is to cause a left shift, making it a less likely answer choice.
**Option C:** This option is incorrect, as increased temperature actually causes a right shift of the oxygen dissociation curve through the Bohr effect.
**Clinical Pearl / High-Yield Fact**
The Bohr effect is a critical concept in respiratory physiology, where an increase in carbon dioxide or a decrease in pH causes a right shift of the oxygen dissociation curve, facilitating the release of oxygen to tissues.
**Correct Answer: C. Increased temperature**
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