VB
Vikas Bhardwaj
Medical Technologist, AIIMS New Delhi
Updated: Apr 17, 2026
**Core Concept**
The question requires the identification of an ideal immunohistochemistry panel for diagnosing a solid-cystic unilateral ovarian tumor composed of small cells with doubtful nuclear grooving and scanty cytoplasm, suggesting a potential germ cell tumor or sex cord-stromal tumor.
**Why the Correct Answer is Right**
This tumor is likely a dysgerminoma, a type of germ cell tumor that typically presents in young women. Dysgerminomas are characterized by a uniform population of small cells with scanty cytoplasm and indistinct cell borders. The absence of Call-Exner bodies, which are characteristic of granulosa cell tumors, further supports this diagnosis. The ideal immunohistochemistry panel for diagnosing dysgerminoma would include markers that are commonly expressed by germ cell tumors, such as OCT4, SOX2, and CD117.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not specified, so we cannot comment on it.
* **Option B:** This option is also not specified, so we cannot comment on it.
* **Option C:** This option is not specified, so we cannot comment on it.
**Clinical Pearl / High-Yield Fact**
Dysgerminomas are highly sensitive to radiation therapy and chemotherapy, and early diagnosis and treatment can improve outcomes. The key to diagnosing dysgerminoma is recognizing the characteristic small cell morphology and using immunohistochemistry to confirm the diagnosis.
**Correct Answer:**
(Note: The correct answer is not specified, but based on the description, the ideal immunohistochemistry panel would likely include OCT4, SOX2, and CD117)