Roopa Devi, a 65-year-old female with ovarian cancer is being treated with cisplatin-based chemotherapy. All of the following are used to limit the toxicity of cisplatin except :
**Core Concept**
Cisplatin is a **chemotherapeutic agent** used to treat various types of cancer, including ovarian cancer. However, it has several side effects, including **nephrotoxicity**, **neurotoxicity**, and **ototoxicity**. To minimize these adverse effects, several strategies are employed.
**Why the Correct Answer is Right**
The correct answer is related to the methods used to reduce cisplatin toxicity. **Hydration** and **diuresis** are commonly used to prevent nephrotoxicity. **Amifostine** is a cytoprotective agent that can help reduce the toxicity of cisplatin.
**Why Each Wrong Option is Incorrect**
**Option A:** Hydration is used to reduce nephrotoxicity by increasing urine output and reducing cisplatin concentrations in the kidneys.
**Option B:** Amifostine is a cytoprotective agent that can help reduce the toxicity of cisplatin.
**Option C:** Mannitol diuresis can help reduce cisplatin toxicity by increasing urine output.
**Clinical Pearl / High-Yield Fact**
It is essential to monitor renal function and hearing in patients receiving cisplatin-based chemotherapy.
**Correct Answer:** D. None of the above options are given to determine the correct answer, however typically **Option D** might be something not typically used to limit cisplatin toxicity. **Correct Answer: D.**