**Core Concept**
Post-menopausal osteoporosis is characterized by a decrease in bone density and strength due to estrogen deficiency. Effective prevention and treatment strategies aim to maintain or increase bone mass, reduce bone resorption, and promote bone formation.

**Why the Correct Answer is Right**
Estrogen replacement therapy (ERT) is a well-established treatment for post-menopausal osteoporosis. Estrogen inhibits osteoclast activity, thereby reducing bone resorption. Additionally, estrogen stimulates osteoblasts, leading to increased bone formation. **Selective estrogen receptor modulators (SERMs)**, such as raloxifene, also mimic the beneficial effects of estrogen on bone while minimizing its risks. **Bisphosphonates**, like alendronate, are another class of medications that prevent bone resorption by inhibiting osteoclast activity.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incomplete.

**Option B:** There is no widely accepted treatment for osteoporosis that involves the use of **calcium channel blockers**.

**Option C:** Although **vitamin D** is essential for bone health, supplementation alone is not sufficient to prevent or treat osteoporosis in post-menopausal women.

**Clinical Pearl / High-Yield Fact**
The **National Osteoporosis Foundation** recommends that post-menopausal women with a history of osteoporotic fractures or those with a 10-year risk of hip fracture of 3% or higher should consider pharmacological therapy to prevent future fractures.

**Correct Answer:** B.