**Core Concept**
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive wear and tear of articular cartilage, leading to bone-on-bone contact and inflammation. The condition affects weight-bearing joints, such as the hips, knees, and spine, as well as non-weight-bearing joints like the hands and fingers.

**Why the Correct Answer is Right**
Osteoarthritis primarily involves joints with high mechanical stress and limited mobility. The condition is more common in joints with a low range of motion, such as the first metacarpophalangeal joint (base of the thumb) and the distal interphalangeal joints (DIP joints) of the fingers. These joints are subjected to repetitive stress and strain, leading to cartilage degeneration and OA development. In contrast, the atlanto-axial joint, which connects the first and second cervical vertebrae, has a wide range of motion and is not typically affected by OA.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is not provided, so we cannot evaluate its correctness.
**Option B:** This option is not provided, so we cannot evaluate its correctness.
**Option C:** This option is not provided, so we cannot evaluate its correctness.
**Option D:** This option is not provided, so we cannot evaluate its correctness.

**Clinical Pearl / High-Yield Fact**
The atlanto-axial joint is a synovial joint that allows for rotational movement of the head, making it less susceptible to osteoarthritis.

**Correct Answer:** C.