Drugs used in treatment of organophosporus poisoning are all except:
**Core Concept**
Organophosphorus (OP) poisoning occurs due to the inhibition of acetylcholinesterase (AChE), an enzyme responsible for the breakdown of acetylcholine (ACh), a neurotransmitter. This leads to an accumulation of ACh at synapses, causing overstimulation of muscarinic and nicotinic receptors, resulting in various systemic symptoms.
**Why the Correct Answer is Right**
The treatment of OP poisoning involves the administration of antidotes that either reactivate AChE or inhibit the action of ACh at its receptors. Atropine, a muscarinic antagonist, is used to counteract the muscarinic effects of excess ACh, such as bradycardia, bronchospasm, and salivation. Pralidoxime (2-PAM) is a reactivator of AChE, which helps to restore the enzyme's activity and break down excess ACh. Diazepam is a benzodiazepine that can be used to manage the anxiety and seizures associated with OP poisoning.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is not relevant to the treatment of OP poisoning.
**Option B:** This option is incorrect because it is not a standard treatment for OP poisoning.
**Option C:** This option is incorrect because it is not typically used in the treatment of OP poisoning.
**Clinical Pearl / High-Yield Fact**
In the treatment of OP poisoning, it is essential to administer atropine and pralidoxime promptly to prevent the progression of symptoms and minimize the risk of complications.
**Correct Answer: D.**