Organophosphate sacked by inhibiting the enzyme acetylcholinesterase. Which type of enzyme inhibitors are they
Correct Answer: Non competitive and Irreversible
Description: Refer Goodman and Gilman 12e 242, Katzung 12e p106 Both organophosphates and Karbonn its cause competitive inhibition of acetylcholinesterase by binding to estaratic site. However organophosphates are Irreversible and most carbamates(except carbamyl and propoxures) are reversible inhibitors. Thus the type of inhibition of acetylcholinesterase caused by organophosphates is competitive and Irreversible
Category:
Pharmacology
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