Organism which can penetrate normal cornea: March 2013 (c)
**Core Concept**
The question is testing the ability to identify an organism that can penetrate a normal cornea, which is an essential aspect of ophthalmology and microbiology. The normal cornea is usually resistant to microbial invasion due to its unique structure and function.
**Why the Correct Answer is Right**
The correct answer is Neisseria gonorrhoeae. This bacterium can penetrate the normal cornea due to its ability to adhere to and invade epithelial cells. Neisseria gonorrhoeae produces pili, which are protein filaments that facilitate attachment to the corneal epithelium. The bacterium then injects its DNA into the host cell, leading to cellular invasion and the initiation of infection. This process is facilitated by the expression of the gonococcal porin, PorA, which allows the bacterium to establish a strong attachment to the host cell.
**Why Each Wrong Option is Incorrect**
**Option A:** Herpes simplex virus is a common cause of corneal ulcers, but it typically requires a compromised corneal epithelium or pre-existing ocular surface disease to infect the cornea.
**Option B:** Pseudomonas aeruginosa is a common cause of corneal ulcers, especially in contact lens wearers, but it typically requires a compromised corneal epithelium to infect the cornea.
**Option C:** Candida albicans is a common cause of fungal keratitis, but it typically requires a compromised corneal epithelium or pre-existing ocular surface disease to infect the cornea.
**Clinical Pearl / High-Yield Fact**
Neisseria gonorrhoeae is a highly infectious and aggressive bacterium that can cause severe and irreversible corneal damage if left untreated. Prompt recognition and treatment are essential to prevent vision loss.
**Correct Answer: C. Neisseria gonorrhoeae**