Organised glomemler deposits in kidney is present in-
**Core Concept**
Organized glomerular deposits refer to the accumulation of immune complexes or other substances within the glomeruli, leading to various kidney diseases. In IgA nephropathy, these deposits are composed of IgA antibodies, which play a crucial role in the disease's pathogenesis.
**Why the Correct Answer is Right**
IgA nephropathy, also known as Berger's disease, is characterized by the deposition of IgA antibodies in the glomeruli. This deposition leads to inflammation, damage to the glomerular basement membrane, and subsequent kidney dysfunction. The IgA antibodies form immune complexes with other substances, such as complement components and fibrinogen, which accumulate in the mesangial region of the glomeruli, causing mesangial proliferation and sclerosis. This process disrupts the normal glomerular filtration barrier, resulting in hematuria, proteinuria, and impaired kidney function.
**Why Each Wrong Option is Incorrect**
**Option A:** Amyloidosis involves the deposition of amyloid fibrils in various tissues, including the kidneys, but these deposits are not organized glomerular deposits characteristic of IgA nephropathy.
**Option B:** Diabetes mellitus can cause diabetic nephropathy, which involves the accumulation of extracellular matrix proteins and mesangial expansion, but it does not typically feature organized glomerular deposits of IgA antibodies.
**Option D:** Cryoglobulinemia involves the deposition of cryoglobulins (immunoglobulins that precipitate at low temperatures) in various tissues, including the kidneys, but these deposits are not typically organized glomerular deposits of IgA antibodies.
**Clinical Pearl / High-Yield Fact**
IgA nephropathy is the most common cause of recurrent or episodic hematuria, particularly following upper respiratory tract infections. It is essential to consider IgA nephropathy in patients with recurrent or persistent hematuria, especially in the absence of other obvious causes.
**β Correct Answer: C. IgA nephropathy**