Organic nitrates can lead to the development of tolerance when used chronically. Which of the following preparations is least likely to develop tolerance:
Correct Answer: Sublingual nitroglycerine
Description: Tolerance develops to nitrates, when these are present constantly in the blood. Sublingual route leads to immediate action of nitrates and these act for a sho time. Other preparations mentioned in the question are more likely to give consistent plasma levels of nitrates leading to development of tolerance.
Category:
Pharmacology
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