**Core Concept**
The question tests knowledge of **steroid hormones** and their characteristics, specifically focusing on oral activity. **Steroid hormones** are a class of hormones that are synthesized from **cholesterol** and include **corticosteroids**, **estrogens**, and **androgens**.

**Why the Correct Answer is Right**
Since the correct answer is not provided, let's discuss the general principle. Orally active hormones are typically **lipid-soluble**, allowing them to survive the **first-pass effect** in the liver and be absorbed through the gastrointestinal tract. **Corticosteroids**, such as **prednisone**, are examples of orally active steroid hormones.

**Why Each Wrong Option is Incorrect**
**Option A:** Without the specific option details, we cannot directly address why each option is incorrect. However, generally, **peptide hormones** like **insulin** are not orally active due to digestion by **gastric enzymes**.
**Option B:** Similarly, without specifics, we can say that **water-soluble hormones** would not be orally active without modification.
**Option C:**
**Option D:**

**Clinical Pearl / High-Yield Fact**
A key point to remember is that **steroid hormones** can be given orally because they are **lipid-soluble**, whereas **peptide hormones** generally cannot due to **digestion** in the gastrointestinal tract.

**Correct Answer:** Not provided.