**Core Concept**
Sacubitril is a neprilysin inhibitor, which increases the levels of natriuretic peptides in the body, thereby exerting a beneficial effect on heart failure.

**Why the Correct Answer is Right**
Sacubitril works by inhibiting the breakdown of natriuretic peptides by neprilysin, leading to an increase in their levels and subsequent vasodilation, reduced blood pressure, and improved cardiac function. The combination of sacubitril with an angiotensin-converting enzyme (ACE) inhibitor (such as valsartan) has been shown to improve outcomes in patients with heart failure. This combination is known as sacubitril/valsartan.

**Why Each Wrong Option is Incorrect**
**Option A:** Sacubitril is not approved for the treatment of hypertension alone. While it may have some effect on blood pressure, its primary indication is for heart failure.
**Option B:** Sacubitril is not a beta-blocker. It works through a different mechanism by inhibiting neprilysin.
**Option C:** Sacubitril is not an ACE inhibitor. It is often used in combination with an ACE inhibitor, but it is a distinct class of medication.

**Clinical Pearl / High-Yield Fact**
Sacubitril/valsartan is a combination medication that has been shown to improve outcomes in patients with heart failure, including reduced hospitalization rates and improved quality of life.

**Correct Answer:** C. Heart failure