**Core Concept**
The patient's symptoms are suggestive of aphthous stomatitis, a common condition characterized by recurrent ulcers on the oral mucosa. This condition is often triggered by stress, anxiety, and other factors, which can be exacerbated by factors like malnutrition, vitamin deficiencies, and immune system dysregulation.

**Why the Correct Answer is Right**
The management of aphthous stomatitis typically involves a combination of topical treatments and stress management techniques. Topical corticosteroids, such as dexamethasone or triamcinolone, can help reduce inflammation and promote healing. Other topical treatments, like lidocaine or benzocaine, can provide relief from pain and discomfort. Stress management techniques, such as relaxation exercises, counseling, or cognitive-behavioral therapy, can also help alleviate symptoms. In this case, given the patient's upcoming board exams, stress management techniques would be an essential part of her management plan.

**Why Each Wrong Option is Incorrect**
**Option A:**
Topical antibiotics, such as penicillin or erythromycin, are not typically indicated for aphthous stomatitis, as the condition is not caused by bacterial infection.

**Option B:**
Systemic corticosteroids, such as prednisone, may be indicated in some cases of aphthous stomatitis, but they are typically reserved for more severe cases or when other treatments have failed.

**Option C:**
Antiviral medications, such as acyclovir, are not typically indicated for aphthous stomatitis, as the condition is not caused by viral infection.

**Option D:**
Antihistamines, such as diphenhydramine, may provide some relief from pain and discomfort, but they are not a primary treatment for aphthous stomatitis.

**Clinical Pearl / High-Yield Fact**
Aphthous stomatitis is a common condition that can be triggered by stress, anxiety, and other factors. Recognizing the role of stress in this condition can help clinicians provide more effective management and support for patients.

**Correct Answer:** B.