**Core Concept**
The question is testing the understanding of postoperative muscle ache, also known as postoperative myalgia, which is a common complication after surgery. This phenomenon is related to the release of various biochemical mediators, including bradykinin, prostaglandins, and histamine, which cause muscle pain and inflammation.

**Why the Correct Answer is Right**
Postoperative muscle ache is primarily caused by the release of bradykinin, a potent vasodilator and smooth muscle contractor. Bradykinin stimulates nociceptors, leading to the transmission of pain signals to the central nervous system. Additionally, prostaglandins, such as PGE2, are also involved in the pathogenesis of postoperative myalgia by sensitizing nociceptors and promoting inflammation.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because while muscle trauma and ischemia may contribute to postoperative pain, they are not the primary cause of postoperative muscle ache.

**Option B:** This option is incorrect because while inflammation and edema are associated with postoperative pain, they are not the direct cause of postoperative muscle ache.

**Option C:** This option is incorrect because while histamine release can contribute to postoperative pain, it is not the primary mediator responsible for postoperative muscle ache.

**Clinical Pearl / High-Yield Fact**
A key point to remember is that postoperative muscle ache is often associated with the release of bradykinin, which can be prevented or alleviated by administering drugs that inhibit bradykinin production, such as ACE inhibitors.

**Correct Answer: B. Inflammation and edema.**