Operation requires and infusion of procainamide. It’s half life is 2hrs. The in fusion is begin at 9:00 a.m. to 1:00 p.m. on the same day, the blood concentration is found to be 3mg/L. What is the probable steady state concentration after 2 days of infusion
Correct Answer: 4mg/L
Description: Ref-Katzung 10/e p40,43,44 Half life of this drug is 2 hours and its plasma concentration is 3 mg/L after 4 hours (9AM to 1 PM). This means, after 2 half lives ( 4 hours) plasma concentration is 3mg/ L. We know, by constant i.v. infusion, plasma concentration attained is 75% of the steady state in 2 half lives. So, if 3 mg/L is 75% of steady state, it will amount to 4 mg/L.
Category:
Anatomy
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now