Onion peel appearance of splenic capsule is seen in
**Core Concept**
The onion peel appearance of the splenic capsule is a histopathological feature seen in a condition characterized by the deposition of amyloid protein in the capsule of the spleen. This condition is associated with chronic inflammation and is often seen in patients with long-standing diseases.
**Why the Correct Answer is Right**
The onion peel appearance is due to the concentric layers of amyloid protein deposited in the splenic capsule, leading to a characteristic layered or lamellated appearance under microscopic examination. Amyloid deposition in the spleen is often seen in conditions such as systemic amyloidosis, where there is a chronic inflammatory process leading to the deposition of amyloid protein.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the onion peel appearance is not typically seen in conditions such as splenic infarction or trauma, which may cause focal damage to the spleen but do not lead to amyloid deposition.
**Option B:** This option is incorrect because the onion peel appearance is not characteristic of conditions such as splenic lymphoma or leukemia, which may cause infiltration of the spleen but do not lead to amyloid deposition.
**Option C:** This option is incorrect because the onion peel appearance is not typically seen in conditions such as splenic abscess or empyema, which may cause focal infection or inflammation in the spleen but do not lead to amyloid deposition.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that the onion peel appearance of the splenic capsule is a characteristic feature of systemic amyloidosis, and its presence should prompt further investigation for underlying chronic inflammatory conditions.
**Correct Answer: A. Chronic amyloidosis**