One of the following diuretic does not require its presence in the tubular lumen for its pharmacological effects
Correct Answer: Aldosterone antagonists
Description: Most of the diuretics act from the luminal side of membrane in the nephron. Thazides,loop diuretics,carbonic anhydrase inhibitors and epithelial Na+ channel blockers are secreted in the proximal tubules through organic anion/cation transpo process. Osmotic diuretics reach the lumen of proximal tubules glomerular filtration. Aldosterone antagonists like spironolactone do not act through luminal side rather they act from basolateral side of the membrane.Therefore,these agents do not require access to the tubular lumen.
Category:
Pharmacology
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