One of the below mentioned penicillin is NOT given orally:
**Core Concept**
Penicillins are a class of antibiotics that can be administered orally or parenterally, depending on their stability in the gastrointestinal tract and absorption characteristics. Oral administration is preferred for penicillins that are not inactivated by gastric acid.
**Why the Correct Answer is Right**
Penicillin G (A) is a narrow-spectrum penicillin that is inactivated by gastric acid, making it unsuitable for oral administration. Instead, it is typically given intravenously or intramuscularly to ensure adequate absorption and efficacy. This is because Penicillin G is rapidly hydrolyzed by gastric acid, resulting in its inactivation.
**Why Each Wrong Option is Incorrect**
**Option B:** Penicillin V is a penicillin that is acid-stable and can be given orally, making it a suitable option for oral administration.
**Option C:** Amoxicillin is another orally administered penicillin that is acid-stable and has a broad spectrum of activity, making it a suitable option for oral use.
**Option D:** Not provided, but typically, other penicillins like Ampicillin can also be given orally.
**Clinical Pearl / High-Yield Fact**
When choosing an oral penicillin, consider the stability of the antibiotic in the gastrointestinal tract and its absorption characteristics. Acid-stable penicillins like Penicillin V and Amoxicillin are suitable for oral administration.
**Correct Answer:** A. Penicillin G