On acclimatizing to new height, our body maintains the body pH by
Correct Answer: Increasing 2,3-DPG
Description: Ans: d (Increasing 2,3-DPG) Ref: Ganong 22nd ed/ p.686AcclimatizationAn acclimatized person is one who has developed compensatory mechanisms, so that hypoxia causes less adverse effects on the body.Compensatory mechanisms in acclimatization:-*Ventilatorv response:-The initial ventilatory response is small as alkalosis tends to counteract effect of hypoxia. However, ventilation increases over the next 4 days. After 4 days, ventilatory response begins to decline slowly.The respiratory alkalosis produced by hyperventilation shifts O2-Hb dissociation curve to the left, but a concomitant increase in 2,3- DPG tends to decrease the O2 affinity of haemoglobin.*Bloodresponse:-Erythropoetin secretion increases and then falls after 4 days.The increase in RBC begins in 2-3 days (polycythemia)* Compensatory changes in tissue:-Mitochondria increases in number.Myoglobin increases.Cytochrome oxidase content increases.
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