Oedema is caused by fall in plasma proteins below
## **Core Concept**
The core concept being tested here is the relationship between plasma protein levels, particularly albumin, and the development of edema. Plasma proteins, especially albumin, contribute to the oncotic pressure that helps retain fluid within blood vessels.
## **Why the Correct Answer is Right**
The correct answer, **C. 5 g/dl**, is based on the fact that edema typically occurs when the plasma albumin level falls below 5 g/dl. Albumin is the most abundant plasma protein and plays a crucial role in maintaining oncotic pressure. When albumin levels drop, the oncotic pressure decreases, leading to fluid leakage from the capillaries into the interstitial space, causing edema. This threshold is critical because it marks the point at which the body's ability to retain fluid within the vascular compartment is compromised.
## **Why Each Wrong Option is Incorrect**
- **Option A: 10 g/dl** - This is significantly higher than the threshold for edema development. Normal albumin levels range approximately from 3.5 to 5.5 g/dl, so 10 g/dl is far above the critical threshold for causing edema.
- **Option B: 3 g/dl** - Although levels below 3.5 g/dl can be associated with hypoalbuminemia, edema typically starts to become more pronounced when levels fall below 5 g/dl, not as high as 3 g/dl.
- **Option D: 1 g/dl** - While very low albumin levels (severe hypoalbuminemia) would certainly cause edema, 1 g/dl is an extremely low level, and edema would already be present at levels above this.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that hypoalbuminemia can result from various conditions, including liver disease (reduced synthesis), nephrotic syndrome (increased loss), and malnutrition (decreased production). The development of edema in these conditions is often multifactorial but is critically influenced by the level of albumin.
## **Correct Answer: C. 5 g/dl**