## Core Concept
Obstructive jaundice is a condition characterized by the blockage of bile flow from the liver to the intestine, leading to the accumulation of bilirubin in the blood. Certain medications can cause cholestasis, a reduction or stoppage of bile flow, which may result in obstructive jaundice.
## Why the Correct Answer is Right
The correct answer, **C. Chlorpromazine**, is a phenothiazine antipsychotic known to cause cholestatic jaundice as a rare but serious side effect. This occurs due to an idiosyncratic reaction leading to intrahepatic cholestasis, which presents with symptoms similar to obstructive jaundice, such as jaundice, dark urine, and pale stools.
## Why Each Wrong Option is Incorrect
* **Option A:** is not directly associated with causing obstructive jaundice or cholestasis as a notable side effect.
* **Option B:** does not have a well-documented association with cholestatic jaundice or obstructive jaundice.
* **Option D:** is not commonly linked with causing obstructive jaundice; its side effects profile does not prominently feature cholestasis.
## Clinical Pearl / High-Yield Fact
A key point to remember is that chlorpromazine and other phenothiazines can cause cholestatic jaundice, which typically presents within the first 1-4 weeks of treatment. This condition is usually reversible upon discontinuation of the drug but can be a serious side effect.
## Correct Answer Line
**Correct Answer: C. Chlorpromazine.**
Free Medical MCQs · NEET PG · USMLE · AIIMS
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