**Question:** Not true about Edward syndrome

A. Edward syndrome is a genetic disorder caused by mutations in multiple genes.
B. Edward syndrome results from a deficiency in the immune system.
C. Edward syndrome primarily affects males.
D. Treatment for Edward syndrome involves surgical interventions.

**Core Concept:** Edward syndrome (also known as Edwards syndrome) is a rare genetic disorder characterized by developmental abnormalities in affected individuals. It is caused by chromosomal abnormalities, specifically the presence of an extra copy of chromosome 18 (trisomy 18). This genetic disorder primarily affects both males and females equally, and not just males as stated in option C.

**Why the Correct Answer is Right:** Option D is incorrect because Edward syndrome is a genetic disorder, not a surgical condition. While medical management may include pain control, respiratory support, and other supportive care, there are no specific surgical interventions for treating the underlying genetic cause.

**Why Each Wrong Option is Incorrect:**

A. Edward syndrome is caused by chromosomal abnormalities, particularly trisomy 18, not mutations in multiple genes as stated in option A.
B. Edward syndrome is a genetic condition, not caused by a deficiency in the immune system as stated in option B.
C. Edward syndrome affects both males and females equally, not just males as stated in option C.

**Clinical Pearl:** Understanding the genetic basis of Edward syndrome is crucial for healthcare professionals to provide appropriate counseling and management options for affected individuals and their families. Adequate knowledge of genetic syndromes and their management can significantly impact patient care and outcomes.

**Correct Answer:** D. Treatment for Edward syndrome involves medical management, including pain control, respiratory support, and other supportive care. Surgery is not a primary treatment option for this genetic disorder.