Not a part of triad of may – Hegglin anomaly
**Core Concept**
May-Hegglin anomaly is a rare genetic disorder characterized by the presence of giant platelets, thrombocytopenia, and inclusion bodies in the neutrophils. The classic triad associated with this condition includes giant platelets, thrombocytopenia, and inclusion bodies in the neutrophils.
**Why the Correct Answer is Right**
The correct answer is not part of the triad of May-Hegglin anomaly. The presence of inclusion bodies in the neutrophils, thrombocytopenia, and giant platelets are the hallmark features of this condition. The inclusion bodies are characteristic needle-like or rod-shaped inclusions in the cytoplasm of neutrophils, which are a key diagnostic feature.
**Why Each Wrong Option is Incorrect**
* **Option A:** is not a part of the triad, but May-Hegglin anomaly is associated with bleeding manifestations and thrombosis due to platelet dysfunction.
* **Option B:** is not a part of the triad, but thrombocytopenia and giant platelets are indeed associated with May-Hegglin anomaly.
* **Option C:** is not a part of the triad, but inclusion bodies in neutrophils are a key feature of May-Hegglin anomaly.
**Clinical Pearl / High-Yield Fact**
May-Hegglin anomaly is a rare condition, but it is essential to recognize the presence of inclusion bodies in neutrophils as a key diagnostic feature. This can be remembered using the mnemonic "GIANT" for Giant Platelets, Inclusion Bodies, Abnormal Neutrophils, Thrombocytopenia.
**Correct Answer:** B. Thrombosis