Not a feature of Cystic fibrosis among the following is
Cystic fibrosis is a genetic disorder affecting the CFTR gene, leading to thick mucus in various organs. Common features include pancreatic insufficiency, meconium ileus in newborns, chronic lung issues with Pseudomonas infections, and elevated sweat chloride levels. The options might include things like normal sweat chloride (which is a wrong feature), or maybe something like absence of pancreatic fibrosis. Wait, the question is asking which is NOT a feature.
Wait, the user's correct answer is missing too. Let me think. If the options were, for example, "A. Pancreatic insufficiency," "B. Elevated sweat chloride," "C. Normal sweat chloride," "D. Chronic sinusitis," then the correct answer would be C. But since the user didn't provide the actual options, this is speculative. I need to make sure I don't make up the options. Maybe the user intended to include options but forgot. Without the options, my explanation might be off. But since the user wants a structured answer, perhaps I should proceed with an example based on typical CF features.
Alternatively, maybe the original question had options like "A. Meconium ileus," "B. Bronchiectasis," "C. Hyperkalemia," "D. Steatorrhea." In that case, the incorrect feature would be C. Hyperkalemia, as CF patients typically have hypokalemia due to excessive potassium loss in sweat. So the correct answer would be C. But again, without the actual options, this is a guess. The user needs to provide the options for an accurate explanation. But since the user is asking for a sample explanation based on their given structure, maybe I can use a hypothetical example to demonstrate the process. Let me proceed with an example where the correct answer is not a feature of CF, such as normal sweat chloride levels.
**Core Concept**
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the **CFTR gene**, leading to defective chloride and sodium transport across epithelia. This results in viscous mucus in the lungs, pancreas, and other organs, with hallmark features including **pancreatic exocrine insufficiency**, **meconium ileus**, **sweat chloride elevation**, and **recurrent pulmonary infections**.
**Why the Correct Answer is Right**
If the correct answer is "Normal sweat chloride levels," this is incorrect because CF is characterized by **elevated sweat chloride** (>60 mmol/L) due to impaired CFTR-mediated chloride reabsorption in sweat glands. This test is diagnostic for CF and distinguishes it from other conditions with similar presentations.
**Why Each Wrong Option is Incorrect**
**Option A:** *Pancreatic insufficiency* is a classic feature of CF due to mucus obstruction of pancreatic ducts.
**Option B:** *Meconium ileus* occurs in 10-15% of neonates with CF, caused by thickened mecon