**Core Concept**
Lisch nodules are pigmented iris hamartomas, which are benign growths composed of melanocytes and other iris tissue. They are a characteristic feature of a specific genetic disorder.

**Why the Correct Answer is Right**
Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is an autosomal dominant disorder caused by mutations in the NF1 gene. Lisch nodules are a hallmark of NF1, typically appearing in the second decade of life and increasing in number with age. They are thought to result from the abnormal growth of melanocytes and other iris cells due to the genetic defect. The presence of Lisch nodules is a diagnostic criterion for NF1.

**Why Each Wrong Option is Incorrect**
**Option A:** Niemann Pick disease is a group of genetic disorders caused by sphingomyelin accumulation in cells, primarily affecting the nervous system and liver. It is not associated with Lisch nodules.
**Option C:** Ochronosis, or alkaptonuria, is a rare genetic disorder characterized by the accumulation of homogentisic acid in connective tissue, leading to pigmentation and joint disease. It is not associated with Lisch nodules.
**Option D:** Glycogen storage diseases are a group of disorders caused by defects in glycogen metabolism, leading to accumulation of glycogen in various tissues. They are not associated with Lisch nodules.

**Clinical Pearl / High-Yield Fact**
Lisch nodules are a key diagnostic feature of Neurofibromatosis type 1 (NF1). They are usually bilateral and multiple, and can be used to screen for NF1 in individuals with a family history of the disorder.

✓ Correct Answer: B. Neurofibromatosis