Nodular glomerulosclerosis is associated with:September 2009 and 2011, September 2012
Correct Answer: Diabetes Mellitus
Description: Ans. D: Diabetes MellitusNodular glomerulosclerosis refers to a histologic pattern of nodular mesangial sclerosis with accentuated, lobular-appearing glomeruli on renal biopsy.Although nodular glomerulosclerosis is classically described in association with diabetes (the so-called "KimmelstielWilson lesion"), the lesion is not pathognomonic for diabetic nephropathy. In fact, a number of renal conditions have been seen in association with this distinctive, histologic pattern.The differential diagnosis of non-diabetic, nodular glomerulosclerosis includes, but is not limited to:Immunotactoid glomerulosnephritisFibrillary glomerulosnephritisFibronectin glomerulosnephritisCryoglobulinemic glomerulosnephritisAmyloidosisLight Chain Deposition Disease (LCDD)Heavy Chain Deposition Disease (HCDD)Idiopathic Nodular GlomerulosclerosisIn order to determine the specific disease responsible for nodular glomerulosclerosis, a deliberate inspection of the renal biopsy (paicularly, Congo red staining) is required.The diagnosis of "idiopathic" nodular glomerulosclerosis remains one of exclusion.
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now