Nitrates act by –
Correct Answer: Activate guanyl cyclase and increase cGMP
Description: Ans. is 'b' i.e., Activate/Guanyl/cyclase and increase cGMP Mechanism of action of nitrates:* Organic nitrates are rapidly denitrated enzymatically in the smooth muscle cell to release nitric oxide (NO) which activates cytosolic guanyl cyclase - | cGMP - Vasodilatation.* Veins express greater amount of the enzyme that generates NO from organic nitrates than arteries - Account for the predominant venodilatory effect.
Category:
Pharmacology
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