**Core Concept**
The recruitment of neutrophils and macrophages to sites of inflammation is a critical step in the innate immune response. This process involves the coordinated action of various chemokines and cytokines that facilitate the migration of these cells from the bloodstream into tissues.

**Why the Correct Answer is Right**
CXCL8, also known as Interleukin-8 (IL-8), is a potent neutrophil and macrophage attractant. It acts by binding to its receptor, CXCR1 and CXCR2, expressed on the surface of these cells, triggering a signaling cascade that leads to their activation and migration towards the site of inflammation. The production of CXCL8 is often upregulated in response to inflammatory stimuli, such as bacterial lipopolysaccharide (LPS) or tissue damage.

**Why Each Wrong Option is Incorrect**
**Option A:** Although CCL2 (MCP-1) is a chemokine involved in the recruitment of monocytes and macrophages, it is not the most potent neutrophil attractant.
**Option B:** IL-1β is a pro-inflammatory cytokine involved in the initiation of the inflammatory response, but it is not a direct attractant of neutrophils and macrophages.
**Option C:** TNF-α is a cytokine that plays a key role in the regulation of the immune response, but it is not a chemokine and does not directly attract neutrophils and macrophages.

**Clinical Pearl / High-Yield Fact**
The recruitment of neutrophils and macrophages is a critical step in the resolution of inflammation, and dysregulation of this process can lead to chronic inflammation and tissue damage.

**Correct Answer: C. CXCL8**