Neurotransmitter present in nigro-striatal pathway is:March 2012
**Core Concept**
The **nigro-striatal pathway** is a crucial component of the brain's motor control system, primarily involved in the regulation of movement. This pathway connects the **substantia nigra** to the **striatum**. The neurotransmitter present in this pathway plays a significant role in motor function.
**Why the Correct Answer is Right**
The correct answer is related to the neurotransmitter **dopamine**, which is the primary neurotransmitter in the nigro-striatal pathway. Dopamine is synthesized from the amino acid **tyrosine** through the action of **tyrosine hydroxylase** and **dopamine decarboxylase**. Dopamine depletion in this pathway is associated with **Parkinson's disease**, characterized by tremors, rigidity, and bradykinesia.
**Why Each Wrong Option is Incorrect**
**Option A:** is incorrect because **serotonin** is primarily involved in mood regulation and is not the main neurotransmitter in the nigro-striatal pathway.
**Option B:** and **Option C:** are also incorrect as they are not directly related to the nigro-striatal pathway.
**Clinical Pearl / High-Yield Fact**
Remember that **dopamine** replacement therapy is a common treatment approach for Parkinson's disease, aiming to restore dopamine levels in the brain and alleviate motor symptoms.
**Correct Answer:** D. Dopamine