**Core Concept**
The question is testing the understanding of the neurochemical basis of bipolar disorder, specifically mania. **Dopamine** and other neurotransmitters play a crucial role in the pathophysiology of mood disorders.

**Why the Correct Answer is Right**
In mania, there is an increase in the release of dopamine, which contributes to the characteristic symptoms of elevated mood, decreased need for sleep, and increased energy. This is due to the overactivation of dopamine receptors in the brain, particularly the D1 and D2 receptors. The increased dopamine release is thought to be mediated by the increased activity of the mesolimbic pathway, which is involved in the regulation of reward and pleasure.

**Why Each Wrong Option is Incorrect**
**Option A:** **Serotonin** is not directly associated with the pathophysiology of mania. While serotonin is involved in mood regulation, its levels are not typically increased in mania.
**Option B:** **GABA** is an inhibitory neurotransmitter, and its levels are not associated with the increased activity seen in mania. In fact, GABA levels are often decreased in individuals with bipolar disorder.
**Option C:** **Glutamate** is an excitatory neurotransmitter, but its levels are not directly linked to the pathophysiology of mania.

**Clinical Pearl / High-Yield Fact**
The use of antipsychotic medications, which block dopamine receptors, can help alleviate symptoms of mania. This is a key concept in the pharmacological treatment of bipolar disorder.

**Correct Answer: C. Glutamate is not the correct answer though.**
A neurotransmitter which is found in increased qualities in mania is **Dopamine**.