Antidepressant drug that can cause neuroleptic malignant syndrome and tardive dyskinesia is:March 2009
**Core Concept**
The question tests knowledge of antidepressant side effects, specifically those related to **dopamine** and **serotonin** pathways. **Neuroleptic malignant syndrome (NMS)** and **tardive dyskinesia** are severe side effects associated with certain psychiatric medications.
**Why the Correct Answer is Right**
Although the specific correct answer is not provided, typically, drugs that can cause NMS and tardive dyskinesia are those that block **dopamine receptors**, such as some antipsychotics. However, among antidepressants, **monoamine oxidase inhibitors (MAOIs)** and certain **tricyclic antidepressants (TCAs)** can indirectly affect dopamine pathways, potentially leading to these conditions.
**Why Each Wrong Option is Incorrect**
**Option A:** Without the specific option, it's hard to comment, but typically, selective serotonin reuptake inhibitors (SSRIs) are less likely to cause these conditions compared to other options.
**Option B:** Similarly, without specifics, but if this option refers to an SSRI or a newer antidepressant, it might be less likely to cause NMS or tardive dyskinesia.
**Option C:** If this were an option like a TCA or an MAOI, it might have some plausible link to these side effects due to its broader pharmacological profile.
**Option D:** Again, without specifics, but if it refers to a drug not known for dopamine blockade or significant impact on dopamine pathways, it would be an unlikely cause.
**Clinical Pearl / High-Yield Fact**
It's crucial to remember that while antidepressants are not the primary drugs associated with NMS and tardive dyskinesia, certain classes, especially those with significant **dopaminergic** effects, can increase the risk of these severe side effects.
**Correct Answer:** Unfortunately, without the answer choices provided, a specific correct answer cannot be given.