**Core Concept**
Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder caused by an adverse reaction to neuroleptic or antipsychotic medications. It is characterized by fever, muscle rigidity, autonomic dysfunction, and altered mental status.
**Why the Correct Answer is Right**
NMS is treated with dantrolene, which is a skeletal muscle relaxant that works by inhibiting calcium ion release from the sarcoplasmic reticulum. This action reduces muscle rigidity and prevents further muscle damage. In addition to dantrolene, supportive care including hydration, cooling, and management of autonomic instability are also essential. Benzodiazepines may be used to manage agitation and seizures, but they do not address the underlying cause of NMS.
**Why Each Wrong Option is Incorrect**
**Option A:** Haloperidol is a typical antipsychotic that can trigger NMS, so it would not be an appropriate treatment.
**Option B:** Metoclopramide is a dopamine antagonist that can exacerbate NMS, making it an incorrect choice.
**Option C:** Chlorpromazine is another typical antipsychotic that can cause NMS, so it is not a suitable treatment.
**Clinical Pearl / High-Yield Fact**
NMS is a medical emergency that requires prompt recognition and treatment. Early recognition and discontinuation of the offending medication can prevent progression to life-threatening complications.
**Correct Answer:** C. Dantrolene is used to treat neuroleptic malignant syndrome.
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