Neurocysticercosis is treated by all the following drugs, EXCEPT –
**Core Concept**
Neurocysticercosis is a parasitic infection of the central nervous system caused by *Taenia solium* larvae. Treatment involves antihelminthic drugs that inhibit parasite metabolism or reduce cyst formation, with a focus on reducing inflammation and preventing progression of neurological symptoms.
**Why the Correct Answer is Right**
Albendazole, flubendazole, and praziquantel are all antihelminthic agents used in neurocysticercosis. They inhibit tubulin polymerization in the parasite, disrupting microtubule function and leading to larval death. Praziquantel is effective in both peripheral and central infections, while albendazole and flubendazole are preferred in CNS cases due to better penetration into the brain. Niclosamide, however, is not effective against *Taenia* species and is primarily used for *Cysticercus cellulosae* in the gut or for *Taenia solium* in intestinal form β it does not cross the blood-brain barrier effectively and lacks activity against brain cysts.
**Why Each Wrong Option is Incorrect**
Option A: Albendazole is a standard first-line treatment for neurocysticercosis due to its ability to inhibit glucose uptake in the parasite.
Option C: Flubendazole is a benzimidazole derivative with similar action to albendazole and is used in CNS infections.
Option D: Praziquantel is effective against *Taenia* cysticerci in the brain and is used in combination with steroids.
**Clinical Pearl / High-Yield Fact**
Niclosamide is not used in neurocysticercosis β it is only effective in intestinal *Taenia* infections and has poor CNS penetration. Always remember: **Neurocysticercosis treatment = Albendazole, Flubendazole, or Praziquantel β not Niclosamide**.
β Correct Answer: B. Niclosamide