The following is true about Nesidioblastosis except?
**Core Concept**
Nesidioblastosis is a rare disorder characterized by hyperplasia of the pancreatic islet cells, leading to excessive insulin production. This results in symptoms such as hypoglycemia, which can be severe and life-threatening.
**Why the Correct Answer is Right**
Nesidioblastosis is most commonly diagnosed in infancy and early childhood, often presenting with symptoms of hypoglycemia, such as seizures, lethargy, and sweating. The condition is often associated with a genetic predisposition, and the hyperplasia of islet cells can be identified on histopathological examination. Diazoxide, a potassium channel activator, is used to treat nesidioblastosis by suppressing insulin release from the abnormal islet cells.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is correct, as nesidioblastosis typically presents with hypoglycemic attacks due to excessive insulin production.
**Option B:** This option is correct, as the histopathology of nesidioblastosis shows hyperplasia of islet cells.
**Option C:** This option is correct, as diazoxide is used to treat nesidioblastosis by suppressing insulin release.
**Clinical Pearl / High-Yield Fact**
It is essential to consider nesidioblastosis in the differential diagnosis of hypoglycemia in infants and young children, as early recognition and treatment can prevent long-term complications.
**Correct Answer:** ✓ Correct Answer: D. More common in adults than in children