Rickets in neonatal period and early infancy present as all EXCEPT:-
**Core Concept**
Rickets in neonatal period and early infancy is a condition caused by vitamin D deficiency, leading to softening of bones. The pathophysiology involves impaired bone mineralization due to insufficient calcium and phosphate availability, resulting from vitamin D's crucial role in calcium absorption.
**Why the Correct Answer is Right**
Rickets in neonates and early infants typically presents with clinical manifestations such as bowed legs, softening of the skull (craniotabes), and delayed closure of the fontanelles. The condition is often associated with symptoms like hypocalcemia, which can lead to seizures or tetany. Vitamin D's role in regulating calcium and phosphate homeostasis is critical in preventing rickets.
**Why Each Wrong Option is Incorrect**
**Option A:** This option should describe a symptom or manifestation of rickets, such as delayed walking or difficulty in sitting without support. However, without seeing the options, I can only infer that this should be a plausible presentation of rickets.
**Option B:** This option could describe a feature of osteomalacia, a condition related to rickets but typically seen in adults. However, without the specific options, it's challenging to determine why this would be incorrect.
**Option C:** This option should describe a symptom or manifestation of rickets, such as softening of the bones, but without seeing the options, I can only infer that this should be a plausible presentation of rickets.
**Option D:** This option should describe a symptom or manifestation of rickets, such as softening of the bones, but without seeing the options, I can only infer that this should be a plausible presentation of rickets.
**Clinical Pearl / High-Yield Fact**
Rickets in neonates and early infants often presents with subtle clinical manifestations, making early diagnosis challenging. A high index of suspicion and timely laboratory testing, including serum vitamin D levels, are crucial in diagnosing and managing this condition.
**Correct Answer:** D.